An interleukin 4 (IL-4)-independent pathway for CD4(+) T cell IL-4 production is revealed in IL-4 receptor-deficient mice

IL-4 receptor α chain (IL-4Rα)-deficient mice were generated by gene-targeting in BALB/c embryonic stem cells. Mutant mice showed a loss of IL-4 signal transduction and functional activity. The lack of IL-4Rα resulted in markedly diminished, but not absent, TH2 responses after infection with the hel...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Noben-Trauth, Nancy, Shultz, Leonard D., Brombacher, Frank, Urban, Joseph F., Gu, Hua, Paul, William E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23501/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380721/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10838
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