Transmission of Simian Immunodeficiency Virus Carrying Multiple Cytotoxic T-Lymphocyte Escape Mutations with Diminished Replicative Ability Can Result in AIDS Progression in Rhesus Macaques

Cytotoxic T-lymphocyte (CTL) responses frequently select for immunodeficiency virus mutations that result in escape from CTL recognition with viral fitness costs. The replication in vivo of such viruses carrying not single but multiple escape mutations in the absence of the CTL pressure has remained...

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Main Authors: Seki, Sayuri, Kawada, Miki, Takeda, Akiko, Igarashi, Hiroko, Sata, Tetsutaro, Matano, Tetsuro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346745/
https://ncbi.nlm.nih.gov/pubmed/18337572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02607-07
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