Effect of Low-Dose Ritonavir on the Pharmacokinetics of the CXCR4 Antagonist AMD070 in Healthy Volunteers

AMD070, a CXCR4 antagonist, has demonstrated antiretroviral activity in human immunodeficiency virus-infected patients. Since AMD070 is a substrate of cytochrome P450 3A4 and P-glycoprotein, both of which may be affected by ritonavir, we tested for a ritonavir effect on AMD070 pharmacokinetics. Subj...

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Autors principals: Cao, Ying Jun, Flexner, Charles W., Dunaway, Shelia, Park, Jeong-Gun, Klingman, Karin, Wiggins, Ilene, Conley, Jeanne, Radebaugh, Christine, Kashuba, Angela D., MacFarland, Ron, Becker, Stephen, Hendrix, Craig W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346642/
https://ncbi.nlm.nih.gov/pubmed/18285477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01460-07
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