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Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore
Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is blocked by highly lyotropic permeant anions which bind tightly within the pore. Here we show that several different substitutions of a positively charged amino acid residue, arginine R334, in...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2003
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2342941/ https://ncbi.nlm.nih.gov/pubmed/12679372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.038232 |
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