An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity

PICK1 is a calcium-sensing, PDZ domain-containing protein that interacts with GluR2 and GluR3 AMPA receptor (AMPAR) subunits and regulates their trafficking. Although PICK1 has been principally implicated in long-term depression (LTD), PICK1 over expression in CA1 pyramidal neurons causes a CaMK- an...

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Bibliografiske detaljer
Main Authors: Terashima, Akira, Pelkey, Kenneth A., Rah, Jong-Cheol, Suh, Young Ho, Roche, Katherine W., Collingridge, Graham L., McBain, Chris J., Isaac, John T.R.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2336895/
https://ncbi.nlm.nih.gov/pubmed/18367088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.01.028
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