Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas

We have examined the effects of inactivation of the p53 tumor suppressor gene on the incidence of apoptotic cell death in two stages of the adenoma-to-carcinoma progression in the intestine: in early adenomas where p53 mutations are rare and in highly dysplastic adenomas where loss of p53 occurs fre...

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Detalhes bibliográficos
Main Authors: Fazeli, Amin, Steen, Robert G., Dickinson, Stephanie L., Bautista, Dolores, Dietrich, William F., Bronson, Roderick T., Bresalier, Robert S., Lander, Eric S., Costa, Jose, Weinberg, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC23339/
https://ncbi.nlm.nih.gov/pubmed/9294187
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