Isolation, Characterization, and Biological Evaluation of Syn and Anti Diastereomers of [(99m)Tc]Technetium Depreotide: a Somatostatin Receptor Binding Tumor Imaging Agent

The early and later eluting [(99m)TcO]depreotide products on RP-HPLC were confirmed to be the anti and syn diastereomers, respectively, based on proton NMR and circular dichroism spectroscopy. NMR provided evidence of a folded, conformationally constrained structure for the syn diastereomer. The syn...

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Detalhes bibliográficos
Main Authors: Cyr, John E., Pearson, Daniel A., Nelson, Carol A., Lyons, Barbara A., Zheng, Yongyong, Bartis, Judit, He, Jiafang, Cantorias, Melchor V., Howell, Robertha C., Francesconi, Lynn C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330168/
https://ncbi.nlm.nih.gov/pubmed/17691760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060887v
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