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Mechanism of Cu(+)-transporting ATPases: Soluble Cu(+) chaperones directly transfer Cu(+) to transmembrane transport sites
As in other P-type ATPases, metal binding to transmembrane metal-binding sites (TM-MBS) in Cu(+)-ATPases is required for enzyme phosphorylation and subsequent transport. However, Cu(+) does not access Cu(+)-ATPases in a free (hydrated) form but is bound to a chaperone protein. Cu(+) transfer from Cu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2329688/ https://ncbi.nlm.nih.gov/pubmed/18417453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711446105 |
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