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Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination

One-third of humans are infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. Sequence analysis of two megabases in 26 structural genes or loci in strains recovered globally discovered a striking reduction of silent nucleotide substitutions compared with other human bacteria...

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Main Authors: Sreevatsan, Srinand, Pan, Xi, Stockbauer, Kathryn E., Connell, Nancy D., Kreiswirth, Barry N., Whittam, Thomas S., Musser, James M.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC23284/
https://ncbi.nlm.nih.gov/pubmed/9275218
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