Tetanus toxin L chain is processed by major histocompatibility complex class I and class II pathways and recognized by CD8(+) or CD4(+) T lymphocytes

Tetanus toxin (TeNT) is a heterodimeric protein antigen, whose light chain (L) is translocated in the cytosol of neuronal target cells specifically to cleave its substrates, vesicle-associated membrane protein-2 (VAMP-2, or synaptobrevin) or cellubrevin. We report that the L chain behaves as a nomin...

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Detalhes bibliográficos
Main Authors: Kerblat, I, Tongiani-Dahshan, S, Aude-Garcia, C, Villiers, M-B, Drouet, C, Marche, P N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2327006/
https://ncbi.nlm.nih.gov/pubmed/10886393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2000.00032.x
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