Concerted activity of host cell factor subregions in promoting stable VP16 complex assembly and preventing interference by the acidic activation domain.

In contrast to our understanding of the roles of Oct-1 and VP16 in VP16-mediated transcriptional activation, virtually nothing is known of the role of the second cellular component, termed host cell factor (HCF), or of its structure-function relationships. We show that the majority of the internal r...

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Autori principali: LaBoissière, S, Walker, S, O'Hare, P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1997
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC232567/
https://ncbi.nlm.nih.gov/pubmed/9372942
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