Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases
We have investigated in rat pheochromacytoma PC12 cells the activation of the mitogen-activated protein kinases ERK1 and ERK2 by the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP). This treatment slowly decreases ATP levels to 30% of control, whereas the internal...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1997
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275188/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9705 |
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