Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action
The phosphorylation of insulin receptor substrate 1 (IRS-1) on tyrosine residues by the insulin receptor (IR) tyrosine kinase is involved in most of the biological responses of insulin. IRS-1 mediates insulin signaling by recruiting SH2 proteins through its multiple tyrosine phosphorylation sites. T...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23245/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9275179/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.18.9660 |
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