Structural studies of the interaction of S-adenosylmethionine with the [4Fe-4S] clusters in biotin synthase and pyruvate formate-lyase activating enzyme

The diverse reactions catalyzed by the radical-SAM superfamily of enzymes are thought to proceed via a set of common mechanistic steps, key among which is the reductive cleavage of S-adenosyl-L-methionine (SAM) by a reduced [4Fe-4S] cluster to generate an intermediate deoxyadenosyl radical. A number...

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Bibliographic Details
Main Authors: Cosper, Michele M., Cosper, Nathaniel J., Hong, Wei, Shokes, Jacob E., Broderick, William E., Broderick, Joan B., Johnson, Michael K., Scott, Robert A.
Format: Artigo
Language:Inglês
Published: Wiley-Blackwell 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323939/
https://ncbi.nlm.nih.gov/pubmed/12824504
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