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Withdrawal from acute morphine dependence is accompanied by increased anxiety-like behavior in the elevated plus maze
Pretreatment with a single moderate dose of morphine (e.g. 5.6-10 mg/kg) 4-24 hr prior to challenge with an opioid antagonist such as naloxone results in reliable expression of behaviors that resemble aversive or emotional consequences of withdrawal from chronic opioid exposure, including suppressio...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323908/ https://ncbi.nlm.nih.gov/pubmed/18308382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.01.013 |
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