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Structural and kinetic characterization of the simplified SH3 domain FP1

The simplified SH3 domain sequence, FP1, obtained in phage display selection experiments has an amino acid composition that is 95% Ile, Lys, Glu, Ala, Gly. Here we use NMR to investigate the tertiary structure of FP1. We find that the overall topology of FP1 resembles that of the src SH3 domain, the...

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Detalhes bibliográficos
Main Authors: Yi, Qian, Rajagopal, Ponni, Klevit, Rachel E., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323857/
https://ncbi.nlm.nih.gov/pubmed/12649436
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