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Prediction of protein domain boundaries from sequence alone

We present here a simple approach to identify domain boundaries in proteins of an unknown three-dimensional structure. Our method is based on the hypothesis that a high-side chain entropy of a region in a protein chain must be compensated by a high-residue interaction energy within the region, which...

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Detalhes bibliográficos
Main Authors: Galzitskaya, Oxana V., Melnik, Bogdan S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323849/
https://ncbi.nlm.nih.gov/pubmed/12649427
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