WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases.
The p21(WAF1/CIP1/sdi1) gene product (WAF1) inhibits DNA replication in vitro (J. Chen, P. Jackson, M. Kirschner, and A. Dutta, Nature 374:386-388, 1995; S. Waga, G. Hannon, D. Beach, and B. Stillman, Nature 369:574-578, 1994), but in vivo studies on the antiproliferative activity of WAF1 have not r...
में बचाया:
| में प्रकाशित: | Mol Cell Biol |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Taylor & Francis
1997
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232340/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234744/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4877 |
| टैग: |
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