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Argonaute2 Is Essential for Mammalian Gastrulation and Proper Mesoderm Formation
Mammalian Argonaute proteins (EIF2C1−4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Ago2) results in gastrulation arrest, ectopic expression of Brachyury (T), and mesoderm expansion. We identify a genetic interaction between Ago2 and T, as Ag...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323323/ https://ncbi.nlm.nih.gov/pubmed/18166081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030227 |
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