The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

Simian virus 40 (SV40) encodes two proteins, large T antigen and small t antigen that contribute to virus-induced tumorigenesis. Both proteins act by targeting key cellular regulatory proteins and altering their function. Known targets of the 708-amino-acid large T antigen include the three members...

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Main Authors: Srinivasan, A, McClellan, A J, Vartikar, J, Marks, I, Cantalupo, P, Li, Y, Whyte, P, Rundell, K, Brodsky, J L, Pipas, J M
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC232328/
https://ncbi.nlm.nih.gov/pubmed/9234732
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