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Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation
Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that reside as inactive precursors in the endoplasmic reticulum (ER) membrane. After sterol depletion, the proteins are transported to the Golgi apparatus, where they are cleaved by site-1 protease (S1P). Cl...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323267/ https://ncbi.nlm.nih.gov/pubmed/18323777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.36 |
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