Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.

Among the mechanisms by which the Ras oncogene induces cellular transformation, Ras activates the mitogen-activated protein kinase (MAPK or ERK) cascade and a related cascade leading to activation of Jun kinase (JNK or SAPK). JNK is additionally regulated by the Ras-related G proteins Rac and Cdc42....

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Tang, Y, Chen, Z, Ambrose, D, Liu, J, Gibbs, J B, Chernoff, J, Field, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4454
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