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Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.

Hepatocyte nuclear factor 4 (HNF4), a liver-enriched transcription factor of the nuclear receptor superfamily, is critical for development and liver-specific gene expression. Here, we demonstrate that its DNA-binding activity is modulated posttranslationally by phosphorylation in vivo, ex vivo, and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Viollet, B, Kahn, A, Raymondjean, M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 1997
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232274/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234678/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.8.4208
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