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High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.

Persistent expression of the gamma-globin genes in adults with deletion types of hereditary persistence of fetal hemoglobin (HPFH) is thought to be mediated by enhancer-like effects of DNA sequences at the 3' breakpoints of the deletions. A transgenic mouse model of deletion-type HPFH was gener...

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Detalhes bibliográficos
Main Authors: Arcasoy, M O, Romana, M, Fabry, M E, Skarpidi, E, Nagel, R L, Forget, B G
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC232055/
https://ncbi.nlm.nih.gov/pubmed/9121456
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