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Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.

The Jak (Janus) family of nonreceptor tyrosine kinases plays a critical role in cytokine signal transduction pathways. In Drosophila melanogaster, the dominant hop(Tum-l) mutation in the Hop Jak kinase causes leukemia-like and other developmental defects. Previous studies have suggested that the Hop...

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Udgivet i:Mol Cell Biol
Principais autores: Luo, H, Rose, P, Barber, D, Hanratty, W P, Lee, S, Roberts, T M, D'Andrea, A D, Dearolf, C R
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231882/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9032284/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.3.1562
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