Lck regulates Vav activation of members of the Rho family of GTPases.

Vav is a member of a family of oncogene proteins that share an approximately 250-amino-acid motif called a Dbl homology domain. Paradoxically, Dbl itself and other proteins containing a Dbl domain catalyze GTP-GDP exchange for Rho family proteins, whereas Vav has been reported to catalyze GTP-GDP ex...

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Bibliographic Details
Main Authors: Han, J, Das, B, Wei, W, Van Aelst, L, Mosteller, R D, Khosravi-Far, R, Westwick, J K, Der, C J, Broek, D
Format: Artigo
Language:Inglês
Published: 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC231859/
https://ncbi.nlm.nih.gov/pubmed/9032261
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