E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis.

Mutations in the retinoblastoma (pRb) tumor suppressor pathway including its cyclin-cdk regulatory kinases, or cdk inhibitors, are a hallmark of most cancers and allow unrestrained E2F-1 transcription factor activity, which leads to unregulated G1-to-S-phase cell cycle progression. Moderate levels o...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Nip, J, Strom, D K, Fee, B E, Zambetti, G, Cleveland, J L, Hiebert, S W
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC231829/
https://ncbi.nlm.nih.gov/pubmed/9032231
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki