The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.

Entry into mitosis requires the activity of the Cdc2 kinase. Cdc2 associates with the B-type cyclins, and the Cdc2-cyclin B heterodimer is in turn regulated by phosphorylation. Phosphorylation of threonine 161 is required for the Cdc2-cyclin B complex to be catalytically active, whereas phosphorylat...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Liu, F, Stanton, J J, Wu, Z, Piwnica-Worms, H
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1997
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9001210/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.2.571
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