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Rapamycin resistance tied to defective regulation of p27Kip1.

The potent antiproliferative activity of the macrolide antibiotic rapamycin is known to involve binding of the drug to its cytosolic receptor, FKBP12, and subsequent interaction with targets of rapamycin, resulting in inhibition of p70 S6 kinase (p70S6K). However, the downstream events that lead to...

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Detalhes bibliográficos
Main Authors: Luo, Y, Marx, S O, Kiyokawa, H, Koff, A, Massagué, J, Marks, A R
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC231677/
https://ncbi.nlm.nih.gov/pubmed/8943329
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