Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells.

The human alpha2-integrin gene is transcriptionally downregulated in a nontumorigenic human mammary epithelial cell line, MTSV1-7, and its clonal variant HB2, overexpressing the Erb-B2 oncogene. In this study, we have used deletion mutations within the alpha2-integrin promoter inserted 5' of the chl...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Ye, J, Xu, R H, Taylor-Papadimitriou, J, Pitha, P M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8887648/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.11.6178
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