A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.

The ErbB family includes four homologous transmembrane tyrosine kinases. Whereas ErbB-1 binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu differentiation factors (NDFs, or neuregulins), and ErbB-2, the most oncogenic family member, is an orphan receptor whose functio...

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Библиографические подробности
Главные авторы: Tzahar, E, Waterman, H, Chen, X, Levkowitz, G, Karunagaran, D, Lavi, S, Ratzkin, B J, Yarden, Y
Формат: Artigo
Язык:Inglês
Опубликовано: 1996
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC231527/
https://ncbi.nlm.nih.gov/pubmed/8816440
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