SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells

Severe acute respiratory syndrome (SARS) is a disease characterized by diffuse alveolar damage. We isolated human alveolar type II cells and maintained them in a highly differentiated state. Type II cell cultures supported SARS-CoV replication as evidenced by RT-PCR detection of viral subgenomic RNA...

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Hauptverfasser: Mossel, Eric C., Wang, Jieru, Jeffers, Scott, Edeen, Karen E., Wang, Shuanglin, Cosgrove, Gregory P., Funk, C. Joel, Manzer, Rizwan, Miura, Tanya A., Pearson, Leonard D., Holmes, Kathryn V., Mason, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312501/
https://ncbi.nlm.nih.gov/pubmed/18022664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.09.045
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