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A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit.

Transcription factor NF-kappaB is generally considered to be a heterodimer with two subunits, p50 and p65. The p50 subunit has been suggested to be generated from its precursor, p105, via the ubiquitin-proteasome pathway. During processing, the C-terminal portion of p105 is rapidly degraded whereas...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Lin, L, Ghosh, S
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1996
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231212/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628291/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2248
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