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The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma.

RET/PTC oncogenes, generated by chromosomal rearrangements in papillary thyroid carcinomas, are constitutively activated versions of proto-RET, a gene coding for a receptor-type tyrosine kinase (TK) whose ligand is still unknown. RET/PTCs encode fusion proteins in which proto-RET TK and C-terminal d...

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Salvato in:
Pubblicato in:Mol Cell Biol
Autori principali: Borrello, M G, Alberti, L, Arighi, E, Bongarzone, I, Battistini, C, Bardelli, A, Pasini, B, Piutti, C, Rizzetti, M G, Mondellini, P, Radice, M T, Pierotti, M A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1996
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231203/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628282/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2151
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