Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors

The mitochondrial outer membrane-anchored monoamine oxidase (MAO) is a biochemically important flavoenzyme that catalyzes the deamination of biogenic and xenobiotic amines. Its two subtypes, MAOA and MAOB, are linked to several psychiatric disorders and therefore are interesting targets for drug des...

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Main Authors: Son, Se-Young, Ma, Jichun, Kondou, Youhei, Yoshimura, Masato, Yamashita, Eiki, Tsukihara, Tomitake
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311356/
https://ncbi.nlm.nih.gov/pubmed/18391214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710626105
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