Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.

We have characterized a phosphoserine binding domain in the coactivator CREB-binding protein (CBP) which interacts with the protein kinase A-phosphorylated, and hence activated, form of the cyclic AMP-responsive factor CREB. The CREB binding domain, referred to as KIX, is alpha helical and binds to...

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Autori principali: Parker, D, Ferreri, K, Nakajima, T, LaMorte, V J, Evans, R, Koerber, S C, Hoeger, C, Montminy, M R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC231049/
https://ncbi.nlm.nih.gov/pubmed/8552098
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