Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid.
The thyroid hormone, retinoic acid (RA), and vitamin D regulate gene expression by binding to similar receptors which act as ligand-inducible transcription factors. Incubation of pituitary GH4C1 cells with nanomolar concentrations of vitamin D markedly reduces the response of the rat growth hormone...
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| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1996
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231006/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.1.318 |
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