The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner.

The cellular homologs of the v-Crk oncogene product are composed exclusively of Src homology region 2 (SH2) and SH3 domains. v-Crk overexpression in fibroblasts causes cell transformation and elevated tyrosine phosphorylation of specific cellular proteins. Among these proteins is a 130-kDa protein,...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Ribon, V, Hubbell, S, Herrera, R, Saltiel, A R
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230977/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524328/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.1.45
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