A mechanism of paraquat toxicity involving nitric oxide synthase
Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O(2⨪)). NO synthase (NOS) has been shown to participate in PQ-induced lung injury. Current theory holds that NO reacts with O(2⨪)...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1999
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23088/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535996/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12760 |
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