Accumulation of a novel spliceosomal complex on pre-mRNAs containing branch site mutations.

Pre-mRNA assembles into spliceosomal complexes in the stepwise pathway E-->A-->B-->C. We show that mutations in the metazoan branchpoint sequence (BPS) have no apparent effect on E complex formation but block the assembly of the A complex and the UV cross-linking of U2 small nuclear ribonuc...

Full description

Saved in:
Bibliographic Details
Main Authors: Champion-Arnaud, P, Gozani, O, Palandjian, L, Reed, R
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC230826/
https://ncbi.nlm.nih.gov/pubmed/7565727
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items