scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase.
Cell mutants of the Ku nuclear DNA-binding complex are ionizing radiation sensitive and show V(D)J recombination defects. Ku binds and activates a catalytic subunit of DNA-dependent protein kinase (DNA-PK), although the substrates for DNA-PK are unknown. We found that scid cell extracts were deficie...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7565721/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.10.5700 |
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