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Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.

The TATA-binding protein (TBP) contains a concave surface that interacts specifically with TATA promoter elements and a convex surface that mediates protein-protein interactions with general and gene-specific transcription factors. Biochemical experiments suggest that interactions between activator...

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Autors principals: Lee, M, Struhl, K
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC230796/
https://ncbi.nlm.nih.gov/pubmed/7565697
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