A 10-amino-acid sequence in the N-terminal A/B domain of thyroid hormone receptor alpha is essential for transcriptional activation and interaction with the general transcription factor TFIIB.

The effects of the thyroid hormone (3,5,3'-triiodo-L-thyronine [T3]) on gene transcription are mediated by nuclear T3 receptors (T3Rs). alpha- and beta-isoform T3Rs (T3R alpha and -beta) are expressed from different genes and are members of a superfamily of ligand-dependent transcription factor...

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Bibliographic Details
Main Authors: Hadzic, E, Desai-Yajnik, V, Helmer, E, Guo, S, Wu, S, Koudinova, N, Casanova, J, Raaka, B M, Samuels, H H
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC230690/
https://ncbi.nlm.nih.gov/pubmed/7623841
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