FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition.
The immunosuppressive drugs FK506 and cyclosporin A block T-lymphocyte proliferation by inhibiting calcineurin, a critical signaling molecule for activation. Multiple intracellular receptors (immunophilins) for these drugs that specifically bind either FK506 and rapamycin (FK506-binding proteins [FK...
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| Publié dans: | Mol Cell Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
1995
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230679/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7542743/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.8.4395 |
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