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Pseudotyping of murine leukemia virus with the envelope glycoproteins of HIV generates a retroviral vector with specificity of infection for CD4-expressing cells

CD4-expressing T cells in lymphoid organs are infected by the primary strains of HIV and represent one of the main sources of virus replication. Gene therapy strategies are being developed that allow the transfer of exogenous genes into CD4(+) T lymphocytes whose expression might prevent viral infec...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Schnierle, Barbara S., Stitz, Jörn, Bosch, Valerie, Nocken, Frank, Merget-Millitzer, Heike, Engelstädter, Martin, Kurth, Reinhard, Groner, Bernd, Cichutek, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23056/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9238030/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.16.8640
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