Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation.

Ítems similars

• The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.
  per: Barber, G N, et al.
  Publicat: (1994)
• A new double-stranded RNA-binding protein that interacts with PKR
  per: Coolidge, Candace J., et al.
  Publicat: (2000)
• The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.
  per: Lee, T G, et al.
  Publicat: (1994)
• Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase.
  per: Barber, G N, et al.
  Publicat: (1993)
• Double-Stranded RNA-Independent Dimerization of Interferon-Induced Protein Kinase PKR and Inhibition of Dimerization by the Cellular P58(IPK) Inhibitor
  per: Tan, Seng-Lai, et al.
  Publicat: (1998)