Trypanosoma brucei mitochondrial guide RNA-mRNA chimera-forming activity cofractionates with an editing-domain-specific endonuclease and RNA ligase and is mimicked by heterologous nuclease and RNA ligase.

RNA editing in trypanosomes has been proposed to occur through transesterification or endonuclease cleavage and RNA ligation reactions. Both models involve a chimeric intermediate in which a guide RNA (gRNA) is joined through its 3' oligo(U) tail to an editing site of the corresponding mRNA. Velocit...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Piller, K J, Decker, C J, Rusché, L N, Sollner-Webb, B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230523/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7539100/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.6.2925
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