Cell culture adaptation of Puumala hantavirus changes the infectivity for its natural reservoir, Clethrionomys glareolus, and leads to accumulation of mutants with altered genomic RNA S segment.

This paper reports the establishment of a model for hantavirus host adaptation. Wild-type (wt) (bank vole-passaged) and Vero E6 cell-cultured variants of Puumala virus strain Kazan were analyzed for their virologic and genetic properties. The wt variant was well adapted for reproduction in bank vole...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Lundkvist, A, Cheng, Y, Sjölander, K B, Niklasson, B, Vaheri, A, Plyusnin, A
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1997
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371614/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.12.9515-9523.1997
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