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Loss of heterozygosity induced by a chromosomal double-strand break

The repair of chromosomal double-strand breaks (DSBs) is necessary for genomic integrity in all organisms. Genetic consequences of misrepair include chromosomal loss, deletion, and duplication resulting in loss of heterozygosity (LOH), a common finding in human solid tumors. Although work with radia...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Moynahan, Mary Ellen, Jasin, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22995/
https://ncbi.nlm.nih.gov/pubmed/9256422
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