Opening of a monomer-monomer interface of the trimeric bacteriophage T4-coded GP45 sliding clamp is required for clamp loading onto DNA

The replication system of bacteriophage T4 uses a trimeric ring-shaped processivity clamp (gp45) to tether the replication polymerase (gp43) to the template-primer DNA. This ring is placed onto the DNA by an ATPase-driven clamp-loading complex (gp44/62) where it then transfers, in closed form, to th...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Latham, Gary J., Dong, Feng, Pietroni, Paola, Dozono, Jody M., Bacheller, Daniel J., von Hippel, Peter H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22945/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535942/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12448
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